Blood Gene Expression Profiling of Neurologic Diseases

Blood gene expression profiling of neurologic diseases: a pilot microarray study.

BACKGROUND Tissue gene expression profiling with arrays measures the transcription of thousands of genes. However, this approach cannot be readily used to guide clinical neurologic practice. OBJECTIVES To determine whether clinical neurologic diseases are associated with unique patterns of up- and down-regulated genes in whole blood and to explore the possibility of using peripheral blood as ...

Gene expression profiling of skin and blood in hidradenitis suppurativa.

Blood-based gene expression profiling in castrate-resistant prostate cancer

Castrate-resistant prostate cancer (CRPC), the most life-threatening form of prostate cancer, has recently been the focus of many successful new treatments. Contemporary trials highlight the heterogeneous prognosis of CRPC as overall survival times vary greatly across different patient sub-groups. As presented in BMC Medicine, Wang et al. identify a blood-based prognostic signature in CRPC. The...

gene expression profiling for cancer targeted therapy

background : lung cancer is still the leading cause of cancer- related deaths and most of themâ  are normally diagnosed in late stages, so there is an urgent need to establish reliable tools for the identification at early stages of the disease. in this study, we use an eleven gene signature test to examine lung biopsy specimens for diagnostic, prognostic & therapeutic purposes. methods : bronc...

Gene expression changes in blood after phlebotomy: implications for gene expression profiling.

Rapidly developing technologies such as quantitative real-time reverse transcriptase–polymerase chain reaction (RT-PCR) and microarrays enable characterization and quantification of nucleic acids in clinical samples. Identification of DNA from pathogens such as bacteria or viruses is already widely used in molecular diagnostics. 1 The use of RNA as a diagnostic tool is currently being investiga...